Anti-BMPR1A antibody (24-200) (STJ22819)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMPR1A (24-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMPR1A |
| Gene ID | 657 |
| Uniprot ID | BMR1A_HUMAN |
| Immunogen Region | 24-200 |
| Immunogen Sequence | QNLDSMLHGTGMKSDSDQKK SENGVTLAPEDTLPFLKCYC SGHCPDDAINNTCITNGHCF AIIEEDDQGETTLASGCMKY EGSDFQCKDSPKAQLRRTIE CCRTNLCNQYLQPTLPPVVI GPFFDGSIRWLVLLISMAVC IIAMIIFSSCFCYKHYCKSI SSRRRYNRDLEQDEAFI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human BMPR1A (NP_004320.2). |
Additional Info
| Tissue Specificity | Highly expressed in skeletal muscle. |
| Post Translational Modifications | Glycosylated. |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2. |
| Protein Name | Bone Morphogenetic Protein Receptor Type-1aBmp Type-1a ReceptorBmpr-1aActivin Receptor-Like Kinase 3Alk-3Serine/Threonine-Protein Kinase Receptor R5Skr5Cd Antigen Cd292 |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein Receptor Type-1a antibodyAnti-Bmp Type-1a Receptor antibodyAnti-Bmpr-1a antibodyAnti-Activin Receptor-Like Kinase 3 antibodyAnti-Alk-3 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R5 antibodyAnti-Skr5 antibodyAnti-Cd Antigen Cd292 antibodyAnti-BMPR1A antibodyAnti-ACVRLK3 antibodyAnti-ALK3 antibody |
Information sourced from Uniprot.org