| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BMP6 |
| Gene ID: | 654 |
| Uniprot ID: | BMP6_HUMAN |
| Immunogen Region: | 375-513 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1). |
| Immunogen Sequence: | SASSRRRQQSRNRSTQSQDV ARVSSASDYNSSELKTACRK HELYVSFQDLGWQDWIIAPK GYAANYCDGECSFPLNAHMN ATNHAIVQTLVHLMNPEYVP KPCCAPTKLNAISVLYFDDN SNVILKKYRNMVVRACGCH |
| Post Translational Modifications | Glycosylated at Asn-454. Glycosylation is crucial for recognition by the activin receptor type I/ACVR1. |
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV. Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression. |
| Protein Name | Bone Morphogenetic Protein 6 Bmp-6 Vg-1-Related Protein Vg-1-R Vgr-1 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 6 antibody Anti-Bmp-6 antibody Anti-Vg-1-Related Protein antibody Anti-Vg-1-R antibody Anti-Vgr-1 antibody Anti-BMP6 antibody Anti-VGR antibody |
Information sourced from Uniprot.org