Anti-BMP5 antibody (Internal) (STJ71563)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BMP5 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Preliminary experiments gave an approx 28kDa band in Human Heart, Prostate and Uterus lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP5 |
| Gene ID | 653 |
| Uniprot ID | BMP5_HUMAN |
| Accession Number | NP_066551.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | YKDRSNNRFENET |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation. Promotes the expression of HAMP, this is repressed by its interaction with ERFE. |
| Protein Name | Bone Morphogenetic Protein 5Bmp-5 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 5 antibodyAnti-Bmp-5 antibodyAnti-BMP5 antibody |
Information sourced from Uniprot.org