Anti-BMP3 antibody (257-306 aa) (STJ91864)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human BMP-3 at the amino acid range 257-306
General Information
| Short Description | Rabbit polyclonal anti-Bone morphogenetic protein 3 (257-306 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMP3 |
| Gene ID | 651 |
| Uniprot ID | BMP3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human BMP-3 at the amino acid range 257-306 |
| Immunogen Region | 257-306 aa |
| Specificity | BMP-3 Polyclonal Antibody detects endogenous levels of BMP-3 protein. |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. |
| Protein Name | Bone Morphogenetic Protein 3Bmp-3Bone Morphogenetic Protein 3aBmp-3aOsteogenin |
| Database Links | |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 3 antibodyAnti-Bmp-3 antibodyAnti-Bone Morphogenetic Protein 3a antibodyAnti-Bmp-3a antibodyAnti-Osteogenin antibodyAnti-BMP3 antibodyAnti-BMP3A antibody |
Information sourced from Uniprot.org