Anti-BMP2 antibody [SAA0423] {PE} (STJA0031082)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationPE
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Bone Morphogenetic Protein 2 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0423 |
| Isotype | IgG2ak |
| Conjugation | PE |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | BMP2 |
| Gene ID | 650 |
| Uniprot ID | BMP2_HUMAN |
Additional Info
| Function | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. |
| Protein Name | Bone Morphogenetic Protein 2Bmp-2Bone Morphogenetic Protein 2aBmp-2a |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-2129379Reactome: R-HSA-8878166Reactome: R-HSA-8939902 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Bone Morphogenetic Protein 2 antibodyAnti-Bmp-2 antibodyAnti-Bone Morphogenetic Protein 2a antibodyAnti-Bmp-2a antibodyAnti-BMP2 antibodyAnti-BMP2A antibody |
Information sourced from Uniprot.org