Anti-BMP10 antibody [SAA0429] {PE} (STJA0030857)

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STJA0030857
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Bone Morphogenetic Protein 10 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0429
Conjugation: PE
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: BMP10
Gene ID: 27302
Uniprot ID: BMP10_HUMAN
Function Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Protein Name Bone Morphogenetic Protein 10
Bmp-10
Database Links Reactome: R-HSA-201451
Reactome: R-HSA-2129379
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 10 antibody
Anti-Bmp-10 antibody
Anti-BMP10 antibody

Information sourced from Uniprot.org

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