Anti-BMP1 antibody (1-50) {Biotin} (STJ500266)

SKU:
STJ500266-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BMP1 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50-0.56 µg/µl
Dilution Range: WB: 1:500
DB: 1:2, 000
ELISA: 1:2, 000
IP: 1:200
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: BMP1
Gene ID: 649
Uniprot ID: BMP1_HUMAN
Immunogen Region: 1-50
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human BMP1 protein.
Tissue Specificity Ubiquitous.
Post Translational Modifications Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion.
Function Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. Isoform BMP1-3: Plays an important role in bone repair by acting as a coactivator of BMP7.
Protein Name Bone Morphogenetic Protein 1
Bmp-1
Mammalian Tolloid Protein
Mtld
Procollagen C-Proteinase
Pcp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-1650814
Reactome: R-HSA-2214320
Reactome: R-HSA-2243919
Reactome: R-HSA-8963896 P13497-3
Cellular Localisation Golgi Apparatus
Trans-Golgi Network
Secreted
Extracellular Space
Extracellular Matrix
Co-Localizes With Postn In The Golgi
Isoform Bmp1-3: Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 1 antibody
Anti-Bmp-1 antibody
Anti-Mammalian Tolloid Protein antibody
Anti-Mtld antibody
Anti-Procollagen C-Proteinase antibody
Anti-Pcp antibody
Anti-BMP1 antibody
Anti-PCOLC antibody

Information sourced from Uniprot.org

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