| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-BIRC6/Apollon (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-3.75µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
BIRC6 |
| Gene ID: |
57448 |
| Uniprot ID: |
BIRC6_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_057336.3 |
| Immunogen Sequence: |
PSSSKELPSDFQL |
| Post Translational Modifications | Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY. |
| Function | Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 6Bir Repeat-Containing Ubiquitin-Conjugating EnzymeBruceRing-Type E3 Ubiquitin Transferase Birc6Ubiquitin-Conjugating Bir Domain Enzyme ApollonApollon |
| Database Links | Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneEndosomeCytoplasmCytoskeletonSpindle PoleMicrotubule Organizing CenterCentrosomeMidbodyMidbody RingExhibits Cell Cycle-Dependent LocalizationConcentrates In A Pericentriolar Compartment In InterphaseMoves Partially To Spindle Poles In MetaphaseAnd Finally Localizes To The Spindle Midzone And The Midbody In Telophase And During CytokinesisOn The MidbodyLocalizes To The Midbody RingAlso Called Flemming BodyIn Interphase CellsLocalizes To The Trans-Golgi Network Membrane And EndosomesDuring CytokinesisA Fraction Moves To The Midzone Where It Specifically Arrives At The Midbody RingAfter Abscission CompletionTravels With The Midbody Remnant Into One Daughter CellAnd Remains Bound To It Until A New Midbody Ring Is Formed During The Next Cell Division |
| Alternative Antibody Names | Anti-Baculoviral Iap Repeat-Containing Protein 6 antibodyAnti-Bir Repeat-Containing Ubiquitin-Conjugating Enzyme antibodyAnti-Bruce antibodyAnti-Ring-Type E3 Ubiquitin Transferase Birc6 antibodyAnti-Ubiquitin-Conjugating Bir Domain Enzyme Apollon antibodyAnti-Apollon antibodyAnti-BIRC6 antibodyAnti-KIAA1289 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
