| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cIAP2 (100-604) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BIRC3 |
| Gene ID: |
330 |
| Uniprot ID: |
BIRC3_HUMAN |
| Immunogen Region: |
100-604 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-604 of human cIAP2 (NP_001156.1). |
| Immunogen Sequence: |
NSVNNLEATSQPTFPSSVTN STHSLLPGTEN |
| Tissue Specificity | Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes. |
| Post Translational Modifications | Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. |
| Protein Name | Baculoviral Iap Repeat-Containing Protein 3Apoptosis Inhibitor 2Api2Cellular Inhibitor Of Apoptosis 2C-Iap2Iap Homolog CInhibitor Of Apoptosis Protein 1Hiap-1Hiap1Ring Finger Protein 49Ring-Type E3 Ubiquitin Transferase Birc3Tnfr2-Traf-Signaling Complex Protein 1 |
| Database Links | Reactome: R-HSA-168638Reactome: R-HSA-168927Reactome: R-HSA-5213460Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5668541Reactome: R-HSA-5675482Reactome: R-HSA-5676594Reactome: R-HSA-5689880Reactome: R-HSA-937041 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Baculoviral Iap Repeat-Containing Protein 3 antibodyAnti-Apoptosis Inhibitor 2 antibodyAnti-Api2 antibodyAnti-Cellular Inhibitor Of Apoptosis 2 antibodyAnti-C-Iap2 antibodyAnti-Iap Homolog C antibodyAnti-Inhibitor Of Apoptosis Protein 1 antibodyAnti-Hiap-1 antibodyAnti-Hiap1 antibodyAnti-Ring Finger Protein 49 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Birc3 antibodyAnti-Tnfr2-Traf-Signaling Complex Protein 1 antibodyAnti-BIRC3 antibodyAnti-API2 antibodyAnti-MIHC antibodyAnti-RNF49 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
