Anti-BIN1 antibody [SRM13367] (STJ11108097)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Myc Box-Dependent-Interacting Protein 1 antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM13367 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB, 1:2000-1:4000IHC-P, 1:500-1:1000IF/ICC, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BIN1 |
| Gene ID | 274 |
| Uniprot ID | BIN1_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Immunogen Sequence | Human |
Additional Info
| Post Translational Modifications | Phosphorylated by protein kinase C. |
| Function | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. |
| Protein Name | Myc Box-Dependent-Interacting Protein 1Amphiphysin IiAmphiphysin-Like ProteinBox-Dependent Myc-Interacting Protein 1Bridging Integrator 1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | Isoform Bin1: NucleusCytoplasmEndosomeCell MembraneSarcolemmaT-TubuleIsoform Iia: Cytoplasm |
| Alternative Antibody Names | Anti-Myc Box-Dependent-Interacting Protein 1 antibodyAnti-Amphiphysin Ii antibodyAnti-Amphiphysin-Like Protein antibodyAnti-Box-Dependent Myc-Interacting Protein 1 antibodyAnti-Bridging Integrator 1 antibodyAnti-BIN1 antibodyAnti-AMPHL antibody |
Information sourced from Uniprot.org