Anti-BIN1 antibody (40-90 aa) (STJ13100758)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide to from aa region 40-90 of human BIN1 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-BIN1 (40-90 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | BIN1 |
| Gene ID | 274 |
| Uniprot ID | BIN1_HUMAN |
| Immunogen | A synthetic peptide to from aa region 40-90 of human BIN1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 40-90 aa |
| Specificity | Specific for BIN1. |
Additional Info
| Post Translational Modifications | Phosphorylated by protein kinase C. |
| Function | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. |
| Protein Name | Myc Box-Dependent-Interacting Protein 1Amphiphysin IiAmphiphysin-Like ProteinBox-Dependent Myc-Interacting Protein 1Bridging Integrator 1 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | Isoform Bin1: NucleusCytoplasmEndosomeCell MembraneSarcolemmaT-TubuleIsoform Iia: Cytoplasm |
| Alternative Antibody Names | Anti-Myc Box-Dependent-Interacting Protein 1 antibodyAnti-Amphiphysin Ii antibodyAnti-Amphiphysin-Like Protein antibodyAnti-Box-Dependent Myc-Interacting Protein 1 antibodyAnti-Bridging Integrator 1 antibodyAnti-BIN1 antibodyAnti-AMPHL antibody |
Information sourced from Uniprot.org