Anti-BHLHE22 antibody (243-293 aa) (STJ195388)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human BHE22 at the amino acid range 243-293
General Information
| Short Description | Rabbit polyclonal anti-Class E basic helix-loop-helix protein 22 (243-293 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BHLHE22 |
| Gene ID | 27319 |
| Uniprot ID | BHE22_HUMAN |
| Immunogen | Synthesized peptide derived from the human BHE22 at the amino acid range 243-293 |
| Immunogen Region | 243-293 aa |
| Specificity | This antibody detects endogenous levels of BHE22 at Human/Mouse |
Additional Info
| Function | Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. |
| Protein Name | Class E Basic Helix-Loop-Helix Protein 22Bhlhe22Class B Basic Helix-Loop-Helix Protein 5Bhlhb5Trinucleotide Repeat-Containing Gene 20 Protein |
| Database Links | Reactome: R-HSA-9762293 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Class E Basic Helix-Loop-Helix Protein 22 antibodyAnti-Bhlhe22 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 5 antibodyAnti-Bhlhb5 antibodyAnti-Trinucleotide Repeat-Containing Gene 20 Protein antibodyAnti-BHLHE22 antibodyAnti-BHLHB5 antibodyAnti-TNRC20 antibody |
Information sourced from Uniprot.org