| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Class E basic helix-loop-helix protein 22 (243-293 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BHLHE22 |
| Gene ID: |
27319 |
| Uniprot ID: |
BHE22_HUMAN |
| Immunogen Region: |
243-293 aa |
| Specificity: |
This antibody detects endogenous levels of BHE22 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human BHE22 at the amino acid range 243-293 |
| Function | Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA. In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal cord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. |
| Protein Name | Class E Basic Helix-Loop-Helix Protein 22Bhlhe22Class B Basic Helix-Loop-Helix Protein 5Bhlhb5Trinucleotide Repeat-Containing Gene 20 Protein |
| Database Links | Reactome: R-HSA-9762293 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Class E Basic Helix-Loop-Helix Protein 22 antibodyAnti-Bhlhe22 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 5 antibodyAnti-Bhlhb5 antibodyAnti-Trinucleotide Repeat-Containing Gene 20 Protein antibodyAnti-BHLHE22 antibodyAnti-BHLHB5 antibodyAnti-TNRC20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
