Anti-BFSP1 antibody (494-544 aa) (STJ194815)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human BFSP1 at the amino acid range 494-544
General Information
| Short Description | Rabbit polyclonal anti-Filensin (494-544 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BFSP1 |
| Gene ID | 631 |
| Uniprot ID | BFSP1_HUMAN |
| Immunogen | Synthesized peptide derived from the human BFSP1 at the amino acid range 494-544 |
| Immunogen Region | 494-544 aa |
| Specificity | This antibody detects endogenous levels of BFSP1 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases. Filensin C-terminal fragment: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433. Filensin N-terminal fragment: Acetylated at Ala-42 following proteolytic cleavage at Leu-41. |
| Function | Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulation of MIP water permeability. |
| Protein Name | FilensinBeaded Filament Structural Protein 1Lens Fiber Cell Beaded-Filament Structural Protein Cp 115Cp115Lens Intermediate Filament-Like HeavyLifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell Cortex |
| Alternative Antibody Names | Anti-Filensin antibodyAnti-Beaded Filament Structural Protein 1 antibodyAnti-Lens Fiber Cell Beaded-Filament Structural Protein Cp 115 antibodyAnti-Cp115 antibodyAnti-Lens Intermediate Filament-Like Heavy antibodyAnti-Lifl-H Cleaved Into - Filensin C-Terminal Fragment - Filensin N-Terminal Fragment antibodyAnti-BFSP1 antibody |
Information sourced from Uniprot.org