Anti-Beta-synuclein antibody (Full-Length) (STJA0040994)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFull-length human recombinant Beta-synuclein protein expressed in and purified from E. Coli.
General Information
| Short Description | Rabbit polyclonal anti-Beta-synuclein (Full-Length) for use in IHC-F and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:1000-1:2000IHC 1:1000-1:2000 |
| Formulation | Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide |
| Storage Instruction | Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C. After reconstitution divide into aliquots and store at-20°C for long-term |
Target Information
| Gene Symbol | SNCB |
| Gene ID | 6620 |
| Uniprot ID | SYUB_HUMAN |
| Immunogen | Full-length human recombinant Beta-synuclein protein expressed in and purified from E. Coli. |
| Immunogen Region | Full-Length |
| Immunogen Sequence | Human |
| Specificity | Validated by Western blotting and immunohistochemical procedures. Specific for Beta-synuclein, does not cross-react with Alpha-or Gamma-synuclein. |
Additional Info
| Tissue Specificity | Expressed predominantly in brain.concentrated in presynaptic nerve terminals. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org