| Short Description : | Rabbit polyclonal anti-Beta-synuclein (C-Term) for use in IHC-F and WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-F/WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG |
| Dilution Range: | WB 1:500-1:1000 |
| Formulation: | Lyophilized from PBS, pH 7.4. Contains no preservative. |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 500 µL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material.Lyophilized at 2-8°C. After reconstitution, store at-20°C in undiluted aliquots for up to 6 months. The antibody |
| Gene Symbol: | SNCB |
| Gene ID: | 6620 |
| Uniprot ID: | SYUB_HUMAN |
| Immunogen: | A synthetic peptide (AQEAAEEPLIEPLME-C) corresponding to human _-synuclein [99-113] in the C-terminal domain conjugated via additional C-terminal Cys to Diphtheria toxoid. |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | Human |
| Specificity: | Confirmed by WB using soluble mouse and human brain extracts, reactivity for major product diminished by peptide absorption. Does not detect alpha-synuclein as tested with recombinant protein and does not react with Lewy bodies in human Dementia with |
| Tissue Specificity | Expressed predominantly in brain.concentrated in presynaptic nerve terminals. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org