Anti-Beta-synuclein antibody (aa: 108-125) (STJA0041012)
SPECIFICATIONS
ClonalityPolyclonal
HostSheep
ConjugationUnconjugated
IsotypeMixed
ImmunogenA synthetic peptide (IEPLMEPEGSYEDPPQE) as part of human beta synuclein protein (aa: 108-125) conjugated to diphteria toxid has been used as the immunogen.
General Information
| Short Description | Sheep polyclonal anti-Beta-synuclein (aa: 108-125) for use in IHC-F in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F |
| Host | Sheep |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | Mixed |
| Conjugation | Unconjugated |
| Purification | Whole serum |
| Dilution Range | IHC 1:3000-1:8000 |
| Storage Instruction | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
Target Information
| Gene Symbol | SNCB |
| Gene ID | 6620 |
| Uniprot ID | SYUB_HUMAN |
| Immunogen | A synthetic peptide (IEPLMEPEGSYEDPPQE) as part of human beta synuclein protein (aa: 108-125) conjugated to diphteria toxid has been used as the immunogen. |
| Immunogen Region | aa: 108-125 |
| Immunogen Sequence | Human |
| Specificity | Known to be specific for beta synuclein. This antiserum is know to react with human, rat and other rodent beta synuclein. |
Additional Info
| Tissue Specificity | Expressed predominantly in brain.concentrated in presynaptic nerve terminals. |
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org