Anti-BDH2/DHRS6 antibody (92-103) (STJ71470)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BDH2/DHRS6 (92-103) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Preliminary experiments in Human Brain (Cerebellum) , Liver and Kidney lysates gave no specific signal but low background (at antibody concentration up to 1ยตg/ml). |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BDH2 |
| Gene ID | 56898 |
| Uniprot ID | DHRS6_HUMAN |
| Accession Number | NP_064524.3 |
| Immunogen Region | 92-103 |
| Immunogen Sequence | DCEEKDWDFSMN |
Additional Info
| Function | NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 6(R-Beta-Hydroxybutyrate Dehydrogenase3-Hydroxybutyrate Dehydrogenase Type 24-Oxo-L-Proline ReductaseOxidoreductase UcpaShort Chain Dehydrogenase/Reductase Family 15c Member 1 |
| Database Links | Reactome: R-HSA-77111 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 6 antibodyAnti-(R-Beta-Hydroxybutyrate Dehydrogenase antibodyAnti-3-Hydroxybutyrate Dehydrogenase Type 2 antibodyAnti-4-Oxo-L-Proline Reductase antibodyAnti-Oxidoreductase Ucpa antibodyAnti-Short Chain Dehydrogenase/Reductase Family 15c Member 1 antibodyAnti-BDH2 antibodyAnti-DHRS6 antibodyAnti-SDR15C1 antibodyAnti-UNQ6308 antibodyAnti-PRO20933 antibody |
Information sourced from Uniprot.org