Anti-BCOR antibody (1231-1280 aa) (STJ91845)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human BCOR at the amino acid range 1231-1280
General Information
| Short Description | Rabbit polyclonal anti-BCL-6 corepressor (1231-1280 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCOR |
| Gene ID | 54880 |
| Uniprot ID | BCOR_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human BCOR at the amino acid range 1231-1280 |
| Immunogen Region | 1231-1280 aa |
| Specificity | BCoR Polyclonal Antibody detects endogenous levels of BCoR protein. |
Additional Info
| Function | Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A.impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells.the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). |
| Protein Name | Bcl-6 CorepressorBcor |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Bcl-6 Corepressor antibodyAnti-Bcor antibodyAnti-BCOR antibodyAnti-KIAA1575 antibody |
Information sourced from Uniprot.org