| Short Description : | Rabbit polyclonal anti-B-cell lymphoma 3 protein (340-420 aa) for use in IHC, IF and WB in Human, Rat, Mouse and Goat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF/WB |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse/Goat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCL3 |
| Gene ID: | 602 |
| Uniprot ID: | BCL3_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 340-420 |
| Immunogen Region: | 340-420 aa |
| Specificity: | BCL3 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation. |
| Protein Name | B-Cell Lymphoma 3 ProteinBcl-3Proto-Oncogene Bcl3 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionUbiquitination Via 'Lys-63'-Linked Ubiquitin Chains Is Required For Nuclear Accumulation |
| Alternative Antibody Names | Anti-B-Cell Lymphoma 3 Protein antibodyAnti-Bcl-3 antibodyAnti-Proto-Oncogene Bcl3 antibodyAnti-BCL3 antibodyAnti-BCL4 antibodyAnti-D19S37 antibody |
Information sourced from Uniprot.org