Anti-BCL11A antibody (STJA0008501)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human BCL11A
General Information
| Short Description | Rabbit polyclonal anti-B-cell lymphoma/leukemia 11A for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BCL11A |
| Gene ID | 53335 |
| Uniprot ID | BC11A_HUMAN |
| Immunogen | Synthesized peptide derived from human BCL11A |
| Specificity | This antibody detects endogenous levels of BCL11A at Human, Mouse |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2. |
| Protein Name | Bcl11 Transcription Factor AB-Cell Cll/Lymphoma 11aB-Cell Lymphoma/Leukemia 11aBcl-11aCoup-Tf-Interacting Protein 1Ecotropic Viral Integration Site 9 Protein HomologEvi-9Zinc Finger Protein 856 |
| Database Links | Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusChromosomeAssociates With The Nuclear BodyColocalizes With Sumo1 And Senp2 In Nuclear SpecklesIsoform 1: Nucleus MatrixColocalizes With Bcl6 In Nuclear ParaspecklesIsoform 2: CytoplasmPredominantly Localized In The Nucleus In Nuclear ParaspecklesIsoform 3: CytoplasmPredominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2In Presence Of Isoform 1 Or Isoform 2Translocates From The Cytoplasm Into Nuclear Paraspeckles |
| Alternative Antibody Names | Anti-Bcl11 Transcription Factor A antibodyAnti-B-Cell Cll/Lymphoma 11a antibodyAnti-B-Cell Lymphoma/Leukemia 11a antibodyAnti-Bcl-11a antibodyAnti-Coup-Tf-Interacting Protein 1 antibodyAnti-Ecotropic Viral Integration Site 9 Protein Homolog antibodyAnti-Evi-9 antibodyAnti-Zinc Finger Protein 856 antibodyAnti-BCL11A antibodyAnti-CTIP1 antibodyAnti-EVI9 antibodyAnti-KIAA1809 antibodyAnti-ZNF856 antibody |
Information sourced from Uniprot.org