| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Putative protein BCE-1 (11-61 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCE1Uniprot ID=BCE1_HUMAN" |
| Immunogen Region: |
11-61 aa |
| Specificity: |
This antibody detects endogenous levels of BCE1 at Human |
| Immunogen: |
Synthesized peptide derived from the human BCE1 at the amino acid range 11-61 |
| Post Translational Modifications | Phosphorylated. PAX5 binding increases phosphorylation. Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. |
| Protein Name | Transducin-Like Enhancer Protein 4Grg-4Groucho-Related Protein 4 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947Reactome: R-HSA-3769402Reactome: R-HSA-4641265 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 4 antibodyAnti-Grg-4 antibodyAnti-Groucho-Related Protein 4 antibodyAnti-TLE4 antibodyAnti-GRG4 antibodyAnti-KIAA1261 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
