| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-BCAS3 microtubule associated cell migration factor (660-740 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BCAS3 |
| Gene ID: |
54828 |
| Uniprot ID: |
BCAS3_HUMAN |
| Immunogen Region: |
660-740 aa |
| Specificity: |
BCAS3 Polyclonal Antibody detects endogenous levels of BCAS3 protein. |
| Immunogen: |
Synthesized peptide derived from BCAS3 at the amino acid range 660-740 |
| Function | Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures. |
| Protein Name | Bcas3 Microtubule Associated Cell Migration FactorBreast Carcinoma-Amplified Sequence 3Gaob1 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonPreautophagosomal StructureLocalizes In The Cytoplasm In Stationary CellsTranslocates From The Cytoplasm To The Leading Edge In Motile CellsColocalizes With Microtubules And Intermediate Filaments In Both Stationary And Motile CellsAssociates With ChromatinRecruited To Estrogen Receptor-Induced Promoters In A Pelp1-Dependent MannerThe Bcas3:Phaf1 Complex Is Recruited To The Preautophagosomal Structures Adjacent To The Damaged Mitochondria Upon Mitophagy In A Prkn-Pink1 Dependent Manner |
| Alternative Antibody Names | Anti-Bcas3 Microtubule Associated Cell Migration Factor antibodyAnti-Breast Carcinoma-Amplified Sequence 3 antibodyAnti-Gaob1 antibodyAnti-BCAS3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
