| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BCAS2 |
| Gene ID: | 10286 |
| Uniprot ID: | SPF27_HUMAN |
| Immunogen Region: | 1-225 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-225 of human BCAS2 (NP_005863.1). |
| Immunogen Sequence: | MAGTGLVAGEVVVDALPYFD QGYEAPGVREAAAALVEEET RRYRPTKNYLSYLTAPDYSA FETDIMRNEFERLAARQPIE LLSMKRYELPAPSSGQKNDI TAWQECVNNSMAQLEHQAVR IENLELMSQHGCNAWKVYNE NLVHMIEHAQKELQKLRKHI QDLNWQRKNMQLTAGSKLRE MESNWVSLVSKNYEIERTIV QLENEIYQIKQQHGEANKEN IRQDF |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). |
| Protein Name | Pre-Mrna-Splicing Factor Spf27Breast Carcinoma-Amplified Sequence 2Dna Amplified In Mammary Carcinoma 1 ProteinSpliceosome-Associated Protein Spf 27 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Spf27 antibodyAnti-Breast Carcinoma-Amplified Sequence 2 antibodyAnti-Dna Amplified In Mammary Carcinoma 1 Protein antibodyAnti-Spliceosome-Associated Protein Spf 27 antibodyAnti-BCAS2 antibodyAnti-DAM1 antibody |
Information sourced from Uniprot.org