Anti-BAP1 antibody [C-4] (STJ16101850)

SKU:
STJ16101850-1

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Host: Mouse
Applications: IHC-P/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-BAP1 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: C-4
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with < 0.1% sodium azide and 0.1% gelatin
Purification: Concentrate
Dilution Range: IHC-P 1:50-1:500
WB 1:100-1:500
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: BAP1
Gene ID: 8314
Uniprot ID: BAP1_HUMAN
Immunogen: Amino acids 430-729 of BAP1 of human origin
Tissue Specificity Highly expressed in testis, placenta and ovary. Expressed in breast.
Post Translational Modifications Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention.
Function Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase Bap1
Brca1-Associated Protein 1
Cerebral Protein 6
Database Links Reactome: R-HSA-5689603
Reactome: R-HSA-5693565
Cellular Localisation Cytoplasm
Nucleus
Mainly Nuclear
Binds To Chromatin
Localizes To The Cytoplasm When Monoubiquitinated By The E2/E3 Hybrid Ubiquitin-Protein Ligase Ube2o
Alternative Antibody Names Anti-Ubiquitin Carboxyl-Terminal Hydrolase Bap1 antibody
Anti-Brca1-Associated Protein 1 antibody
Anti-Cerebral Protein 6 antibody
Anti-BAP1 antibody
Anti-KIAA0272 antibody
Anti-hucep-6 antibody

Information sourced from Uniprot.org

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