| Function | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest. |
| Protein Name | Protein BanpBen Domain-Containing Protein 1Btg3-Associated Nuclear ProteinScaffold/Matrix-Associated Region-1-Binding Protein |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Banp antibodyAnti-Ben Domain-Containing Protein 1 antibodyAnti-Btg3-Associated Nuclear Protein antibodyAnti-Scaffold/Matrix-Associated Region-1-Binding Protein antibodyAnti-BANP antibodyAnti-BEND1 antibodyAnti-SMAR1 antibody |
Information sourced from Uniprot.org
