Anti-BANP antibody (1-260) (STJ29732)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BANP (1-260) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BANP |
| Gene ID | 54971 |
| Uniprot ID | BANP_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MMSEHDLADVVQIAVEDLSP DHPVVLENHVVTDEDEPALK RQRLEINCQDPSIKSFLYSI NQTICLRLDSIEAKLQALEA TCKSLEEKLDLVTNKQHSPI QVPMVAGSPLGATQTCNKVR CAVPGRRQNTIVVKVPGQED SHHEDGESGSEASDSVSSCG QAGSQSIGSNVTLITLNSEE DYPNGTWLGDENNPEMRVRC AIIPSDMLHISTNCRTAEKM ALTLLDYLFHREVQAVSNL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BANP (NP_060339.2). |
Additional Info
| Tissue Specificity | Down-regulated in breast cancer cell lines. |
| Post Translational Modifications | MAPK1/MAPK3-mediated phosphorylation at Thr-337 and Thr-352 results in export to the cytoplasm. |
| Function | Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest. Plays a role in the regulation of alternative splicing. Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10. |
| Protein Name | Protein BanpBen Domain-Containing Protein 1Btg3-Associated Nuclear ProteinScaffold/Matrix-Associated Region-1-Binding Protein |
| Database Links | Reactome: R-HSA-6804759 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmPrimarily Nuclear But Translocates To The Cytoplasm Following Mapk1/Mapk3-Mediated Phosphorylation |
| Alternative Antibody Names | Anti-Protein Banp antibodyAnti-Ben Domain-Containing Protein 1 antibodyAnti-Btg3-Associated Nuclear Protein antibodyAnti-Scaffold/Matrix-Associated Region-1-Binding Protein antibodyAnti-BANP antibodyAnti-BEND1 antibodyAnti-SMAR1 antibody |
Information sourced from Uniprot.org