Anti-BAK1 antibody (N-Term) (STJ70129)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BAK1 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 25kDa band observed in Human Adrenal Gland lysates and in preliminary testing of HeLa and Jurkat cell lyate (calculated MW of 23.4kDa according to NP_001179.1. Recommended conce |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BAK1 |
| Gene ID | 578 |
| Uniprot ID | BAK_HUMAN |
| Accession Number | NP_001179.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | ASGQGPGPPRQE |
Additional Info
| Function | Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. |
| Protein Name | Bcl-2 Homologous Antagonist/KillerApoptosis Regulator BakBcl-2-Like Protein 7Bcl2-L-7 |
| Database Links | Reactome: R-HSA-111452Reactome: R-HSA-111457Reactome: R-HSA-5620971 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Bcl-2 Homologous Antagonist/Killer antibodyAnti-Apoptosis Regulator Bak antibodyAnti-Bcl-2-Like Protein 7 antibodyAnti-Bcl2-L-7 antibodyAnti-BAK1 antibodyAnti-BAK antibodyAnti-BCL2L7 antibodyAnti-CDN1 antibody |
Information sourced from Uniprot.org