Anti-Bak antibody [R03-6A8] (STJA0034067)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Bak
General Information
| Short Description | Rabbit monoclonal anti-Bak for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-6A8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BAK1 |
| Gene ID | 578 |
| Uniprot ID | BAK_HUMAN |
| Immunogen | A synthetic peptide of human Bak |
Additional Info
| Tissue Specificity | Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. |
| Function | Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. |
| Protein Name | Bcl-2 Homologous Antagonist/KillerApoptosis Regulator BakBcl-2-Like Protein 7Bcl2-L-7 |
| Database Links | Reactome: R-HSA-111452Reactome: R-HSA-111457Reactome: R-HSA-5620971 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Bcl-2 Homologous Antagonist/Killer antibodyAnti-Apoptosis Regulator Bak antibodyAnti-Bcl-2-Like Protein 7 antibodyAnti-Bcl2-L-7 antibodyAnti-BAK1 antibodyAnti-BAK antibodyAnti-BCL2L7 antibodyAnti-CDN1 antibody |
Information sourced from Uniprot.org