• HEK293 lysate (10ug protein in RIPA buffer) over expressing Human BAIAP2 with DYKDDDDK tag probed with STJ70062 (1. 0 ug/ml) in Lane A and probed with anti-DYKDDDDK Tag (1/3000) in lane C. Mock-transfected HEK293 probed with STJ70062 (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.

Anti-BAIAP2-isoform 3 antibody (C-Term) (STJ70062)

SKU:
STJ70062-100

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Host: Goat
Applications: Pep-ELISA/WB-Trf/IHC
Reactivity: Human/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BAIAP2-isoform 3 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-3.75µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BAIAP2
Gene ID: 10458
Uniprot ID: BAIP2_HUMAN
Immunogen Region: C-Term
Accession Number: NP_006331.1
Specificity: This antibody will recognise only one of three reported isoforms (NP_006331.1).
Immunogen Sequence: SMSSADVEVARF
Post Translational Modifications Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
Function Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Protein Name Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2
Bai-Associated Protein 2
Bai1-Associated Protein 2
Protein Bap2
Fas Ligand-Associated Factor 3
Flaf3
Insulin Receptor Substrate P53/P58
Irs-58
Irsp53/58
Insulin Receptor Substrate Protein Of 53 Kda
Irsp53
Insulin Receptor Substrate P53
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-4420097
Reactome: R-HSA-5663213
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013423
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Membrane
Peripheral Membrane Protein
Cell Projection
Filopodium
Ruffle
Cytoskeleton
Detected Throughout The Cytoplasm In The Absence Of Specific Binding Partners
Detected In Filopodia And Close To Membrane Ruffles
Recruited To Actin Pedestals That Are Formed Upon Infection By Bacteria At Bacterial Attachment Sites
Alternative Antibody Names Anti-Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 antibody
Anti-Bai-Associated Protein 2 antibody
Anti-Bai1-Associated Protein 2 antibody
Anti-Protein Bap2 antibody
Anti-Fas Ligand-Associated Factor 3 antibody
Anti-Flaf3 antibody
Anti-Insulin Receptor Substrate P53/P58 antibody
Anti-Irs-58 antibody
Anti-Irsp53/58 antibody
Anti-Insulin Receptor Substrate Protein Of 53 Kda antibody
Anti-Irsp53 antibody
Anti-Insulin Receptor Substrate P53 antibody
Anti-BAIAP2 antibody

Information sourced from Uniprot.org

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