Anti-BAIAP2 antibody (362-521) (STJ27290)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BAIAP2 (362-521) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BAIAP2 |
| Gene ID | 10458 |
| Uniprot ID | BAIP2_HUMAN |
| Immunogen Region | 362-521 |
| Immunogen Sequence | PRSSSMAAGLERNGRMRVKA IFSHAAGDNSTLLSFKEGDL ITLLVPEARDGWHYGESEKT KMRGWFPFSYTRVLDSDGSD RLHMSLQQGKSSSTGNLLDK DDLAIPPPDYGAASRAFPAQ TASGFKQRPYSVAVPAFSQG LDDYGARSMSSGSGTLVSTV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 362-521 of human BAIAP2 (NP_059344.1). |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by INSR in response to insulin treatment. |
| Function | Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. |
| Protein Name | Bar/Imd Domain-Containing Adapter Protein 2Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2Bai-Associated Protein 2Bai1-Associated Protein 2Protein Bap2Fas Ligand-Associated Factor 3Flaf3Insulin Receptor Substrate P53/P58Irs-58Irsp53/58Insulin Receptor Substrate Protein Of 53 KdaIrsp53Insulin Receptor Substrate P53 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleCytoskeletonDetected Throughout The Cytoplasm In The Absence Of Specific Binding PartnersDetected In Filopodia And Close To Membrane RufflesRecruited To Actin Pedestals That Are Formed Upon Infection By Bacteria At Bacterial Attachment Sites |
| Alternative Antibody Names | Anti-Bar/Imd Domain-Containing Adapter Protein 2 antibodyAnti-Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2 antibodyAnti-Bai-Associated Protein 2 antibodyAnti-Bai1-Associated Protein 2 antibodyAnti-Protein Bap2 antibodyAnti-Fas Ligand-Associated Factor 3 antibodyAnti-Flaf3 antibodyAnti-Insulin Receptor Substrate P53/P58 antibodyAnti-Irs-58 antibodyAnti-Irsp53/58 antibodyAnti-Insulin Receptor Substrate Protein Of 53 Kda antibodyAnti-Irsp53 antibodyAnti-Insulin Receptor Substrate P53 antibodyAnti-BAIAP2 antibody |
Information sourced from Uniprot.org