| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transcription regulator protein BACH2 (250-330 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BACH2 |
| Gene ID: |
60468 |
| Uniprot ID: |
BACH2_HUMAN |
| Immunogen Region: |
250-330 aa |
| Specificity: |
BACH2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 250-330 |
| Post Translational Modifications | Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export. The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses. |
| Function | Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation. |
| Protein Name | Transcription Regulator Protein Bach2Btb And Cnc Homolog 2 |
| Cellular Localisation | CytoplasmNucleusNucleocytoplasmic Shuttling Is Controlled By Phosphorylation |
| Alternative Antibody Names | Anti-Transcription Regulator Protein Bach2 antibodyAnti-Btb And Cnc Homolog 2 antibodyAnti-BACH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
