Anti-BACH1 antibody [R05-1W-6] (STJA0033079)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenPeptide
General Information
| Short Description | Mouse monoclonal anti-BACH1 for use in WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-1W-6 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein G |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS, Glycerol and BSA |
| Storage Instruction | Store at-20°C. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BACH1 |
| Gene ID | 571 |
| Uniprot ID | BACH1_HUMAN |
| Immunogen | Peptide |
Additional Info
| Post Translational Modifications | Ubiquitinated by the SCF(FBXL17) complex or by the by the SCF(FBXO22) complex, leading to its degradation by the proteasome. Under oxidative stress, reactive oxygen species covalently modify cysteine residues on the bZIP domain of BACH1 and release it from chromatin. If the BTB domain of BACH1 remains intact, its beta1-alpha6 degron is recognized by FBXO22, promoting its ubiquitination and degradation. If the structural integrity of the beta1-alpha6 degron is compromised, FBXL17 will transiently associate with the BACH1 BTB dimer and remodel it into stably bound monomer for ubiquitination and degradation. |
| Function | Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK. Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway. |
| Protein Name | Transcription Regulator Protein Bach1Btb And Cnc Homolog 1Ha2303 |
| Database Links | Reactome: R-HSA-9707587Reactome: R-HSA-9707616Reactome: R-HSA-9708530Reactome: R-HSA-9818027 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Regulator Protein Bach1 antibodyAnti-Btb And Cnc Homolog 1 antibodyAnti-Ha2303 antibodyAnti-BACH1 antibody |
Information sourced from Uniprot.org