Anti-BACE2 antibody (210-290 aa) (STJ192506)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 210-290
General Information
| Short Description | Rabbit polyclonal anti-Beta-secretase 2 (210-290 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BACE2 |
| Gene ID | 25825 |
| Uniprot ID | BACE2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 210-290 |
| Immunogen Region | 210-290 aa |
| Specificity | BACE2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Undergoes autoproteolytic cleavage. Glycosylated. |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. |
| Protein Name | Beta-Secretase 2Aspartic-Like Protease 56 KdaAspartyl Protease 1Asp1Asp 1Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2Beta-Site App Cleaving Enzyme 2Down Region Aspartic ProteaseDrapMemapsin-1Membrane-Associated Aspartic Protease 1Theta-Secretase |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusEndoplasmic ReticulumEndosomeMelanosomeColocalizes With Pmel In Stage I And Ii Melanosomes |
| Alternative Antibody Names | Anti-Beta-Secretase 2 antibodyAnti-Aspartic-Like Protease 56 Kda antibodyAnti-Aspartyl Protease 1 antibodyAnti-Asp1 antibodyAnti-Asp 1 antibodyAnti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibodyAnti-Beta-Site App Cleaving Enzyme 2 antibodyAnti-Down Region Aspartic Protease antibodyAnti-Drap antibodyAnti-Memapsin-1 antibodyAnti-Membrane-Associated Aspartic Protease 1 antibodyAnti-Theta-Secretase antibodyAnti-BACE2 antibodyAnti-AEPLC antibodyAnti-ALP56 antibodyAnti-ASP21 antibodyAnti-CDA13 antibodyAnti-UNQ418 antibodyAnti-PRO852 antibody |
Information sourced from Uniprot.org