Anti-BAAT antibody (309-418) (STJ29960)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BAAT (309-418) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BAAT |
| Gene ID | 570 |
| Uniprot ID | BAAT_HUMAN |
| Immunogen Region | 309-418 |
| Immunogen Sequence | YLFPIEEAQGQFLFIVGEGD KTINSKAHAEQAIGQLKRHG KNNWTLLSYPGAGHLIEPPY SPLCCASTTHDLRLHWGGEV IPHAAAQEHAWKEIQRFLRK HLIPDVTSQL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 309-418 of human BAAT (NP_001692.1). |
Additional Info
| Tissue Specificity | Expressed in the gallbladder mucosa and pancreas. Expressed in hepatocytes (at protein level). |
| Function | Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and taurine. Amidation of BAs in the liver with glycine or taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism. This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates lipid and vitamin absorption. May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. |
| Protein Name | Bile Acid-Coa -Amino Acid N-AcyltransferaseBacatBatBile Acid-Coa ThioesteraseCholoyl-Coa HydrolaseGlycine N-CholoyltransferaseLong-Chain Fatty-Acyl-Coa Hydrolase |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-193368Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmCytosolPeroxisome |
| Alternative Antibody Names | Anti-Bile Acid-Coa -Amino Acid N-Acyltransferase antibodyAnti-Bacat antibodyAnti-Bat antibodyAnti-Bile Acid-Coa Thioesterase antibodyAnti-Choloyl-Coa Hydrolase antibodyAnti-Glycine N-Choloyltransferase antibodyAnti-Long-Chain Fatty-Acyl-Coa Hydrolase antibodyAnti-BAAT antibody |
Information sourced from Uniprot.org