Anti-B7H4 antibody [R08-7G4] (STJA0034061)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human B7H4
General Information
| Short Description | Rabbit monoclonal anti-B7H4 for use in WB, IHC-F, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-7G4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | VTCN1 |
| Gene ID | 79679 |
| Uniprot ID | VTCN1_HUMAN |
| Immunogen | Recombinant protein of human B7H4 |
Additional Info
| Tissue Specificity | Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Protein Name | V-Set Domain-Containing T-Cell Activation Inhibitor 1B7 Homolog 4B7-H4B7h.5Immune Costimulatory Protein B7-H4Protein B7s1T-Cell Costimulatory Molecule B7x |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExpressed At The Cell SurfaceA Soluble Form Has Also Been Detected |
| Alternative Antibody Names | Anti-V-Set Domain-Containing T-Cell Activation Inhibitor 1 antibodyAnti-B7 Homolog 4 antibodyAnti-B7-H4 antibodyAnti-B7h.5 antibodyAnti-Immune Costimulatory Protein B7-H4 antibodyAnti-Protein B7s1 antibodyAnti-T-Cell Costimulatory Molecule B7x antibodyAnti-VTCN1 antibodyAnti-B7H4 antibodyAnti-UNQ659 antibodyAnti-PRO1291 antibody |
Information sourced from Uniprot.org