Anti-B3GNT5 antibody (36-378) (STJ116638)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal B3GNT5 (36-378) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | B3GNT5 |
| Gene ID | 84002 |
| Uniprot ID | B3GN5_HUMAN |
| Immunogen Region | 36-378 |
| Immunogen Sequence | DNHIVSHMKSYSYRYLINSY DFVNDTLSLKHTSAGPRYQY LINHKEKCQAQDVLLLLFVK TAPENYDRRSGIRRTWGNEN YVRSQLNANIKTLFALGTPN PLEGEELQRKLAWEDQRYND IIQQDFVDSFYNLTLKLLMQ FSWANTYCPHAKFLMTADDD IFIHMPNLIEYLQSLEQIGV QDFWIGRVHRGAPPIRDKSS KYYVSYEMYQWPAYPDYTAG AAYVISGDVAAKVYEASQT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 36-378 of human B3GNT5 (NP_114436.1). |
Additional Info
| Tissue Specificity | Widely expressed. Highly expressed in lung, colon, placenta, testis, pituitary gland and cerebellum. Weakly expressed in brain, liver, spleen, lymph node and thymus. |
| Function | Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer.paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. |
| Protein Name | Lactosylceramide 1 -3-N-Acetyl-Beta-D-GlucosaminyltransferaseLactotriaosylceramide SynthaseLc(3cer SynthaseLc3 SynthaseUdp-Glcnac -Beta-Gal Beta-1 -3-N-Acetylglucosaminyltransferase 5Bgnt-5Beta-1 -3-Gn-T5Beta-1 -3-N-Acetylglucosaminyltransferase 5Beta3gn-T5 |
| Database Links | Reactome: R-HSA-913709Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Lactosylceramide 1 -3-N-Acetyl-Beta-D-Glucosaminyltransferase antibodyAnti-Lactotriaosylceramide Synthase antibodyAnti-Lc(3cer Synthase antibodyAnti-Lc3 Synthase antibodyAnti-Udp-Glcnac -Beta-Gal Beta-1 -3-N-Acetylglucosaminyltransferase 5 antibodyAnti-Bgnt-5 antibodyAnti-Beta-1 -3-Gn-T5 antibodyAnti-Beta-1 -3-N-Acetylglucosaminyltransferase 5 antibodyAnti-Beta3gn-T5 antibodyAnti-B3GNT5 antibody |
Information sourced from Uniprot.org