Anti-AZIN1 antibody (STJA0006982)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Antizyme inhibitor 1
General Information
| Short Description | Rabbit polyclonal anti-antizyme inhibitor 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AZIN1 |
| Gene ID | 51582 |
| Uniprot ID | AZIN1_HUMAN |
| Immunogen | Synthesized peptide derived from human Antizyme inhibitor 1 |
| Specificity | This antibody detects endogenous levels of Antizyme inhibitor 1 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated, leading to its proteasomal degradation.a process that is reduced in presence of antizyme OAZ1. |
| Function | Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. |
| Protein Name | Antizyme Inhibitor 1AziAzi1Ornithine Decarboxylase Antizyme Inhibitor |
| Database Links | Reactome: R-HSA-350562 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Antizyme Inhibitor 1 antibodyAnti-Azi antibodyAnti-Azi1 antibodyAnti-Ornithine Decarboxylase Antizyme Inhibitor antibodyAnti-AZIN1 antibodyAnti-OAZI antibodyAnti-OAZIN antibody |
Information sourced from Uniprot.org