Anti-AXIN2 antibody (743-843) (STJ26209)

Name: Anti-AXIN2 antibody (743-843) (STJ26209)
SKU: STJ26209
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ26209

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Short Description	Rabbit polyclonal AXIN2 (743-843) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 IHC-P:1:50-1:100 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	AXIN2
Gene ID	8313
Uniprot ID	AXIN2_HUMAN
Immunogen Region	743-843
Immunogen Sequence	APEDHKEPKKLAGVHALQAS ELVVTYFFCGEEIPYRRMLK AQSLTLGHFKEQLSKKGNYR YYFKKASDEFACGAVFEEIW EDETVLPMYEGRILGKVERI D
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 743-843 of human AXIN2 (NP_004646.3).

Tissue Specificity	Expressed in brain and lymphoblast.
Post Translational Modifications	Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function	Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Protein Name	Axin-2 Axin-Like Protein Axil Axis Inhibition Protein 2 Conductin
Database Links	Reactome: R-HSA-201681 Reactome: R-HSA-4411364 Reactome: R-HSA-4641257 Reactome: R-HSA-5689880
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Axin-2 antibody Anti-Axin-Like Protein antibody Anti-Axil antibody Anti-Axis Inhibition Protein 2 antibody Anti-Conductin antibody Anti-AXIN2 antibody

Information sourced from Uniprot.org