| Short Description : | Rabbit polyclonal AVIL (470-819) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AVIL |
| Gene ID: | 10677 |
| Uniprot ID: | AVIL_HUMAN |
| Immunogen Region: | 470-819 |
| Immunogen Sequence: | AAVQVRVRMGTEPRHFMAIF KGKLVIFEGGTSRKGNAEPD PPVRLFQIHGNDKSNTKAVE VPAFASSLNSNDVFLLRTQA EHYLWYGKGSSGDERAMAKE LASLLCDGSENTVAEGQEPA EFWDLLGGKTPYANDKRLQQ EILDVQSRLFECSNKTGQFV VTEITDFTQDDLNPTDVMLL DTWDQVFLWIGAEANATEKE SALATAQQYLHTHPSGRDPD TPILIIKQGFEPPIFTGWF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-819 of human AVIL (NP_006567.3). |
| Tissue Specificity | Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. Expressed in podocytes (at protein level). |
| Function | Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly. |
| Protein Name | AdvillinP92 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCell JunctionFocal AdhesionNeuron ProjectionAxonIn PodocytesPresent In The F-Actin-Enriched Cell Periphery That Generates Lamellipodia And Focal Adhesions |
| Alternative Antibody Names | Anti-Advillin antibodyAnti-P92 antibodyAnti-AVIL antibody |
Information sourced from Uniprot.org
