| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AVIL (470-819) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AVIL |
| Gene ID: |
10677 |
| Uniprot ID: |
AVIL_HUMAN |
| Immunogen Region: |
470-819 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 470-819 of human AVIL (NP_006567.3). |
| Immunogen Sequence: |
AAVQVRVRMGTEPRHFMAIF KGKLVIFEGGTSRKGNAEPD PPVRLFQIHGNDKSNTKAVE VPAFASSLNSNDVFLLRTQA EHYLWYGKGSSGDERAMAKE LASLLCDGSENTVAEGQEPA EFWDLLGGKTPYANDKRLQQ EILDVQSRLFECSNKTGQFV VTEITDFTQDDLNPTDVMLL DTWDQVFLWIGAEANATEKE SALATAQQYLHTHPSGRDPD TPILIIKQGFEPPIFTGWF |
| Tissue Specificity | Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. Expressed in podocytes (at protein level). |
| Function | Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly. |
| Protein Name | AdvillinP92 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCell JunctionFocal AdhesionNeuron ProjectionAxonIn PodocytesPresent In The F-Actin-Enriched Cell Periphery That Generates Lamellipodia And Focal Adhesions |
| Alternative Antibody Names | Anti-Advillin antibodyAnti-P92 antibodyAnti-AVIL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
