| Tissue Specificity | Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus. Expressed in podocytes (at protein level). |
| Function | Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly. |
| Protein Name | AdvillinP92 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionLamellipodiumCell JunctionFocal AdhesionNeuron ProjectionAxonIn PodocytesPresent In The F-Actin-Enriched Cell Periphery That Generates Lamellipodia And Focal Adhesions |
| Alternative Antibody Names | Anti-Advillin antibodyAnti-P92 antibodyAnti-AVIL antibody |
Information sourced from Uniprot.org
