Anti-AURKC antibody (N-Term) (STJ72141)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-AURKC (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 36kDa band observed in Human Testis lysates (calculated MW of 35.6kDa according to NP_001015878.1). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | AURKC |
| Gene ID | 6795 |
| Uniprot ID | AURKC_HUMAN |
| Accession Number | NP_001015878.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | PRAVVQLGKAQP |
| Specificity | This antibody is expected to recognize isoform 1 (NP_001015878.1) only. |
Additional Info
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Aurora Kinase C antibodyAnti-Aurora 3 antibodyAnti-Aurora/Ipl1-Related Kinase 3 antibodyAnti-Ark-3 antibodyAnti-Aurora-Related Kinase 3 antibodyAnti-Aurora/Ipl1/Eg2 Protein 2 antibodyAnti-Serine/Threonine-Protein Kinase 13 antibodyAnti-Serine/Threonine-Protein Kinase Aurora-C antibodyAnti-AURKC antibodyAnti-AIE2 antibodyAnti-AIK3 antibodyAnti-AIRK3 antibodyAnti-ARK3 antibodyAnti-STK13 antibody |
Information sourced from Uniprot.org