| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-AURKC (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
AURKC |
| Gene ID: |
6795 |
| Uniprot ID: |
AURKC_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_001015878.1 |
| Specificity: |
This antibody is expected to recognize isoform 1 (NP_001015878.1) only. |
| Immunogen Sequence: |
PRAVVQLGKAQP |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase CAurora 3Aurora/Ipl1-Related Kinase 3Ark-3Aurora-Related Kinase 3Aurora/Ipl1/Eg2 Protein 2Serine/Threonine-Protein Kinase 13Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | NucleusChromosomeCentromereCytoplasmCytoskeletonSpindleDistributes In The Condensed Chromosomes During Prophase To MetaphaseAfter Entering AnaphaseThere Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone MicrotubulesAnd Finally Remains In The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Aurora Kinase C antibodyAnti-Aurora 3 antibodyAnti-Aurora/Ipl1-Related Kinase 3 antibodyAnti-Ark-3 antibodyAnti-Aurora-Related Kinase 3 antibodyAnti-Aurora/Ipl1/Eg2 Protein 2 antibodyAnti-Serine/Threonine-Protein Kinase 13 antibodyAnti-Serine/Threonine-Protein Kinase Aurora-C antibodyAnti-AURKC antibodyAnti-AIE2 antibodyAnti-AIK3 antibodyAnti-AIRK3 antibodyAnti-ARK3 antibodyAnti-STK13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
