| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AURKC |
| Gene ID: | 6795 |
| Uniprot ID: | AURKC_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human AURKC (NP_001015878.1). |
| Immunogen Sequence: | MSSPRAVVQLGKAQPAGEEL ATANQTAQQPSSPAMRRLTV DDFEIGRPLGKGKFGNVYLA RLKESHFIVALKVLFKSQIE KEGLEHQLRREIEIQAHLQH |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase. |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. |
| Protein Name | Aurora Kinase C Aurora 3 Aurora/Ipl1-Related Kinase 3 Ark-3 Aurora-Related Kinase 3 Aurora/Ipl1/Eg2 Protein 2 Serine/Threonine-Protein Kinase 13 Serine/Threonine-Protein Kinase Aurora-C |
| Cellular Localisation | Nucleus Chromosome Centromere Cytoplasm Cytoskeleton Spindle Distributes In The Condensed Chromosomes During Prophase To Metaphase After Entering Anaphase There Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone Microtubules And Finally Remains In The Midbody During Cytokinesis |
| Alternative Antibody Names | Anti-Aurora Kinase C antibody Anti-Aurora 3 antibody Anti-Aurora/Ipl1-Related Kinase 3 antibody Anti-Ark-3 antibody Anti-Aurora-Related Kinase 3 antibody Anti-Aurora/Ipl1/Eg2 Protein 2 antibody Anti-Serine/Threonine-Protein Kinase 13 antibody Anti-Serine/Threonine-Protein Kinase Aurora-C antibody Anti-AURKC antibody Anti-AIE2 antibody Anti-AIK3 antibody Anti-AIRK3 antibody Anti-ARK3 antibody Anti-STK13 antibody |
Information sourced from Uniprot.org
