| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Lipid droplet-regulating VLDL assembly factor AUP1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AUP1 |
| Gene ID: |
550 |
| Uniprot ID: |
AUP1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of AUP1 at Human, Rat |
| Immunogen: |
Synthesized peptide derived from human AUP1 |
| Post Translational Modifications | Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection. |
| Function | Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles. |
| Protein Name | Lipid Droplet-Regulating Vldl Assembly Factor Aup1Ancient Ubiquitous Protein 1 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinLipid DropletCytoplasmic VesicleAutophagosome(Microbial Infection) Upon Dengue Virus InfectionRelocates From Lipid Droplets To Autophagosomes |
| Alternative Antibody Names | Anti-Lipid Droplet-Regulating Vldl Assembly Factor Aup1 antibodyAnti-Ancient Ubiquitous Protein 1 antibodyAnti-AUP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
