| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ataxin-7 (260-340 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ATXN7 |
| Gene ID: |
6314 |
| Uniprot ID: |
ATX7_HUMAN |
| Immunogen Region: |
260-340 aa |
| Specificity: |
ATX7 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 260-340 |
| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7). The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration. Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex. |
| Function | Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. |
| Protein Name | Ataxin-7Spinocerebellar Ataxia Type 7 Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Isoform A: NucleusNucleusNucleolusNucleus MatrixCytoplasmCytoskeletonIn Addition To A Diffuse Distribution Throughout The NucleusIt Is Associated With The Nuclear Matrix And The NucleolusIt Is Able To Shuttle Between The Nucleus And CytoplasmIsoform B: Cytoplasm |
| Alternative Antibody Names | Anti-Ataxin-7 antibodyAnti-Spinocerebellar Ataxia Type 7 Protein antibodyAnti-ATXN7 antibodyAnti-SCA7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
