Anti-ATXN7 antibody (260-340 aa) (STJ190569)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 260-340
General Information
| Short Description | Rabbit polyclonal anti-Ataxin-7 (260-340 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATXN7 |
| Gene ID | 6314 |
| Uniprot ID | ATX7_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 260-340 |
| Immunogen Region | 260-340 aa |
| Specificity | ATX7 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Proteolytically cleaved by caspase-7 (CASP7). The cleavage may be involved in SCA7 degeneration: the isoform fragments may exert distinct toxic influences that could contribute to selective neurodegeneration. Sumoylation decreases the aggregation propensity and cellular toxicity of forms with an expanded poly-Gln region but has no effect on subcellular location or interaction with components of the STAGA complex. |
| Function | Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex. Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation. Probably involved in tethering the deubiquitination module within the SAGA complex. Necessary for microtubule cytoskeleton stabilization. Involved in neurodegeneration. |
| Protein Name | Ataxin-7Spinocerebellar Ataxia Type 7 Protein |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Isoform A: NucleusNucleusNucleolusNucleus MatrixCytoplasmCytoskeletonIn Addition To A Diffuse Distribution Throughout The NucleusIt Is Associated With The Nuclear Matrix And The NucleolusIt Is Able To Shuttle Between The Nucleus And CytoplasmIsoform B: Cytoplasm |
| Alternative Antibody Names | Anti-Ataxin-7 antibodyAnti-Spinocerebellar Ataxia Type 7 Protein antibodyAnti-ATXN7 antibodyAnti-SCA7 antibody |
Information sourced from Uniprot.org