| Short Description : | Rabbit polyclonal ATXN10 (346-475) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATXN10 |
| Gene ID: | 25814 |
| Uniprot ID: | ATX10_HUMAN |
| Immunogen Region: | 346-475 |
| Immunogen Sequence: | ETTNIFSNCGCVRAEGDISN VANGFKSHLIRLIGNLCYKN KDNQDKVNELDGIPLILDNC NISDSNPFLTQWVIYAIRNL TEDNSQNQDLIAKMEEQGLA DASLLKKVGFEVEKKGEKLI LKSTRDTPKP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1). |
| Tissue Specificity | Expressed in the central nervous system. |
| Post Translational Modifications | Polyubiquitinated. Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. |
| Function | May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis. |
| Protein Name | Ataxin-10Brain Protein E46 HomologSpinocerebellar Ataxia Type 10 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionMidbodyCytoskeletonCilium Basal BodyMicrotubule Organizing CenterCentrosomeCentrioleLocalizes To The Midbody During Telophase |
| Alternative Antibody Names | Anti-Ataxin-10 antibodyAnti-Brain Protein E46 Homolog antibodyAnti-Spinocerebellar Ataxia Type 10 Protein antibodyAnti-ATXN10 antibodyAnti-SCA10 antibody |
Information sourced from Uniprot.org
