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Anti-ATP7B nanobody [SAA1241] (STJN000209)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Copper-Transporting Atpase 2 is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | ELISA/IF |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1241 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | ATP7B |
| Gene ID | 540 |
| Uniprot ID | ATP7B_HUMAN |
Additional Info
| Post Translational Modifications | Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form. |
| Function | Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. |
| Protein Name | Copper-Transporting Atpase 2Copper Pump 2Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda |
| Database Links | Reactome: R-HSA-936837 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMulti-Pass Membrane ProteinLate EndosomePredominantly Found In The Trans-Golgi Network (Tgn)Localized In The Trans-Golgi Network Under Low Copper ConditionsRedistributes To Cytoplasmic Vesicles When Cells Are Exposed To Elevated Copper LevelsAnd Then Recycles Back To The Trans-Golgi Network When Copper Is RemovedIsoform 1: Golgi Apparatus MembraneIsoform 2: CytoplasmWnd/140 Kda: Mitochondrion |
| Alternative Nanobody Names | Anti-Copper-Transporting Atpase 2 nanobodyAnti-Copper Pump 2 nanobodyAnti-Wilson Disease-Associated Protein Cleaved Into - Wnd/140 Kda nanobodyAnti-ATP7B nanobodyAnti-PWD nanobodyAnti-WC1 nanobodyAnti-WND nanobody |
Information sourced from Uniprot.org