Anti-ATP6V1B1 antibody (381-430 aa) (STJ96223)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ATP6V1B1 at the amino acid range 381-430
General Information
| Short Description | Rabbit polyclonal anti-V-type proton ATPase subunit B, kidney isoform (381-430 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP6V1B1 |
| Gene ID | 525 |
| Uniprot ID | VATB1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ATP6V1B1 at the amino acid range 381-430 |
| Immunogen Region | 381-430 aa |
| Specificity | V-ATPase B1 Polyclonal Antibody detects endogenous levels of V-ATPase B1 protein. |
Additional Info
| Function | Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Essential for the proper assembly and activity of V-ATPase. In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification. Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium. |
| Protein Name | V-Type Proton Atpase Subunit B - Kidney IsoformV-Atpase Subunit B 1Endomembrane Proton Pump 58 Kda SubunitVacuolar Proton Pump Subunit B 1 |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-77387Reactome: R-HSA-917977Reactome: R-HSA-9639288Reactome: R-HSA-983712 |
| Cellular Localisation | Apical Cell MembraneBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-V-Type Proton Atpase Subunit B - Kidney Isoform antibodyAnti-V-Atpase Subunit B 1 antibodyAnti-Endomembrane Proton Pump 58 Kda Subunit antibodyAnti-Vacuolar Proton Pump Subunit B 1 antibodyAnti-ATP6V1B1 antibodyAnti-ATP6B1 antibodyAnti-VATB antibodyAnti-VPP3 antibody |
Information sourced from Uniprot.org