Anti-ATP6IP2/Renin receptor antibody (C-Term) (STJ70436)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ATP6IP2/Renin receptor (C-Term) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/FC |
| Host | Goat |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 38-39kDa band observed in Human Cerebellum and in Human and Rat Heart lysates (calculated MW of 39.0kDa according to Human NP_005756.2 and Rat NP_001007092.1). Recommended concen |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP6AP2 |
| Gene ID | 10159 |
| Uniprot ID | RENR_HUMAN |
| Accession Number | NP_005756.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | SIIYRMTNQKIRMD |
Additional Info
| Post Translational Modifications | Phosphorylated. Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. |
| Function | Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission. |
| Protein Name | Renin ReceptorAtpase H(+-Transporting Lysosomal Accessory Protein 2Atpase H(+-Transporting Lysosomal-Interacting Protein 2Er-Localized Type I Transmembrane AdapterEmbryonic Liver Differentiation Factor 10N14fRenin/Prorenin ReceptorVacuolar Atp Synthase Membrane Sector-Associated Protein M8-9Atp6m8-9V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneCytoplasmic VesicleAutophagosome MembraneCell ProjectionDendritic Spine MembraneAxonEndosome MembraneClathrin-Coated Vesicle MembraneSecretory VesicleSynaptic Vesicle Membrane |
| Alternative Antibody Names | Anti-Renin Receptor antibodyAnti-Atpase H(+-Transporting Lysosomal Accessory Protein 2 antibodyAnti-Atpase H(+-Transporting Lysosomal-Interacting Protein 2 antibodyAnti-Er-Localized Type I Transmembrane Adapter antibodyAnti-Embryonic Liver Differentiation Factor 10 antibodyAnti-N14f antibodyAnti-Renin/Prorenin Receptor antibodyAnti-Vacuolar Atp Synthase Membrane Sector-Associated Protein M8-9 antibodyAnti-Atp6m8-9 antibodyAnti-V-Atpase M8.9 Subunit Cleaved Into - Renin Receptor N-Terminal Fragment - Renin Receptor C-Terminal Fragment antibodyAnti-ATP6AP2 antibodyAnti-ATP6IP2 antibodyAnti-CAPER antibodyAnti-ELDF10 antibodyAnti-HT028 antibodyAnti-MSTP009 antibodyAnti-PSEC0072 antibody |
Information sourced from Uniprot.org